Simple route for elaboration of the hydroxy-ketone and dihydroxy-acetone side-chains of corticosteroids from 17-oxo-steroids
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 775-777
- https://doi.org/10.1039/c39810000775
Abstract
α-Formylaminoacrylic esters, produced by the condensation of ethyl isocyanoacetate with 17-oxo-steroids, have been reduced selectively to give the corresponding alcohols; the latter gave, in high yield, the hydroxyacetyl side-chain on acidic hydrolysis or the dihydroxy-acetone side-chain after appropriate oxidation and hydrolysis.Keywords
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