URINARY BILE ACID CONJUGATES IN EXTRAHEPATIC BILIARY ATRESIA

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Abstract
Summary: The urinary excretion of bile acid conjugates was studied after the administration of 24‐14C‐labelled chenodeoxycholic acid and cholic acid and their corresponding glycine conjugates labelled with glycine‐l‐14T in 5 infants with extrahepatic biliary atresia. Chenodeoxycholic acid‐24‐14C and chenodeoxycholyl[l‐14C]glycine were mainly excreted in the form of labelled metabolites with the TLC behaviour of monosulphates of tauro‐ and glycochenodeoxycholate and glycochenodeoxycholate, respectively. Most of the cholic acid‐24‐14C and the cholyl[l‐14C]glycine were found to be excreted in the form of glycocholate. All labelled bile acids were excreted in conjugated form.