ENZYMOLOGY OF TUBERCLE BACILLI AND OTHER MYCOBACTERIA V

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Abstract
The previously demonstrated inhibition of the diamine oxidase of Mycobacterium smegmatis by streptomycin and dihydrostreptomycin is seen to be a general bacterial phenomenon, for this oxidative enzyme is equally inhibited in M. avium, M. tuberculosis var. hominis, Pseudomonas aeruginosa, and Micrococcus pyogenes var. aureus. The bacterial diamine oxidase is inhibited not only by streptomycin and dihydrostreptomycin, but by such other antibiotic agents as pyocyanin, streptothricin, and chloramphenicol. A wide variety of synthetic amines were also inhibitory: 1-p-nitrophenyl-2-amino-l, 3-propanediol, ephedrine, 4-acetylaminobenzaldehyde thiosemi-carbazone (TB1), promin, and 2-(4[image]aminophenyl-pyridine), in addition to the previously reported diguanidine derivative arcaine.