MR tagging early after myocardial infarction in mice demonstrates contractile dysfunction in adjacent and remote regions

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Abstract
The purpose of this study was to use MR myocardial tagging to assess regional cardiac function after myocardial infarction (MI) in mice. Eight mice were imaged before and 1 day after MI. MRI included cine imaging, myocardial tagging, and contrast-enhanced imaging. Regional percent circumferential shortening (%CS) was measured from the tagged images, and the region of hyperenhancement on the contrast-enhanced images was used to determine the infarcted, adjacent, and remote zones. Ejection fraction (EF) fell from 59% ± 6% at baseline to 32% ± 6% after MI (P < 0.01). At baseline, %CS was 14.5% ± 3.4%. After MI, %CS was 0.7% ± 4.4% in the infarcted zone, 7.4% ± 4.4% in the adjacent zone, and 11.8% ± 4.2% in the remote zone. %CS was statistically different for all comparisons between the infarcted, adjacent, remote, and baseline groups (P < 0.01). MR tagging can detect regional differences in myocardial function post-MI in mice. Magn Reson Med 48:399–403, 2002.