Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I
- 15 May 1983
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 212 (2) , 521-524
- https://doi.org/10.1042/bj2120521
Abstract
Malonyl-CoA inhibition of [rat liver mitochondria] carnitine palmitoyltransferase I was very pH-dependent. Malonyl-CoA concentrations causing 50% inhibition (I50) at pH 6.0, 6.5, 7.0, 7.5 and 8.0 were 0.04, 1, 9, 40 and 200 .mu.M, respectively. A lowering of intracellular pH, such as might occur in ketoacidosis, may attenuate hepatic fatty acid oxidation by increasing malonyl-CoA sensitivity of carnitine palmitoyltransferase I.This publication has 20 references indexed in Scilit:
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