COMPARISON OF THE EFFECTS OF CHOLECYSTOKININ AND CHOLECYSTOKININ OCTAPEPTIDE ON PANCREATIC-SECRETION, GALLBLADDER CONTRACTION, AND PLASMA PANCREATIC-POLYPEPTIDE IN MAN

  • 1 January 1980
    • journal article
    • research article
    • Vol. 96  (4) , 743-748
Abstract
To assess the possible clinical utility of the C-terminal CCK-OP [cholecystokinin-octapeptide] as a stimulus to exocrine and endocrine pancreatic secretion and gallbladder contraction in man, increasing doses of CCK [cholecystokinin] (0.066, 0.125, 0.25 and 0.5 CHR U[Crick-Harper-Raper unit]/Kg per and CCK-OP (20, 40, 80 and 160 ng/kg per h) in random order by constant i.v. infusion to 6 healthy volunteers. Standard intestinal perfusion methods were used and duodenal outputs of lipase, trypsin, bicarbonate and total bile acids and plasma levels of HPP [human pancreatic polypeptide] were measured. CCK-OP, in a dose of 40 ng/kg per h given simultaneously with i.v. administered secretin, produced maximal pancreatic enzyme secretion and gallbladder contraction comparable to that induced by CCK. CCK-OP plus secretin produced only small increased in plasma HPP levels, whereas values after all doses of CCK were significantly higher (P < 0.05) and were similar to values caused by a meal. The combination of i.v. CCK-OP (40 ng/kg per plus secretin (0.25 U/kg per) should be an accurate and relatively inexpensive test of exocrine pancreatic function and gallbladder contraction in man. An undefined component of 20% CCK is a potent stimulus for HPP release.

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