Phenacein - an angiotensin-converting enzyme inhibitor produced by a streptomycete. II. Isolation, structure determination and synthesis.

Abstract
Phenacein, an inhibitor of angiotensin-converting enzyme and antibacterial drug, was isolated from the fermentation broth of a Streptomyces species belonging to the S. tanashiensis-zaomyceticus group. The inhibitor was shown to be 3,6-dihydroxy-1-phenazinecarboxylic acid by spectroscopic, degradative and synthetic methods.

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