Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
- 1 November 1995
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 11 (3) , 241-247
- https://doi.org/10.1038/ng1195-241
Abstract
Genetic studies are under way for many complex traits, spurred by the recent feasibility of whole genome scans. Clear guidelines for the interpretation of linkage results are needed to avoid a flood of false positive claims. At the same time, an overly cautious approach runs the risk of causing true hints of linkage to be missed. We address this problem by proposing specific standards designed to maintain rigor while also promoting communication.Keywords
This publication has 28 references indexed in Scilit:
- Identifying complex disease genes: progress and paradigmsNature Genetics, 1994
- Diminished support for linkage between manic depressive illness and X–chromosome markers in three Israeli pedigreesNature Genetics, 1993
- Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order AmishNature, 1989
- Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigreeNature, 1988
- Localization of a susceptibility locus for schizophrenia on chromosome 5Nature, 1988
- Genetic linkage between X-chromosome markers and bipolar affective illnessNature, 1987
- Bipolar affective disorders linked to DNA markers on chromosome 11Nature, 1987
- On the lod score method in linkage analysisAnnals of Human Genetics, 1984
- Report of the committee on unassigned syntenic groups and theoretical considerationsCytogenetic and Genome Research, 1975
- Theoretical StatisticsPublished by Springer Nature ,1974