Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro.
Open Access
- 1 April 1988
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 8 (4) , 1809-1811
- https://doi.org/10.1128/mcb.8.4.1809
Abstract
The possibility of DNA-binding proteins interacting in vitro with the polymerase II transcriptional machinery was explored by using a competition assay with individual target sequences for enhancer-binding factors. Transcription factors binding to at least five specific enhancer sequences mediate the activity of the human cytomegalovirus immediate-early 1 gene in vitro. Furthermore, our data suggest that individual DNA-bound enhancer factors can interact with the promoter transcription complex.This publication has 12 references indexed in Scilit:
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