Mammalian Toxicological Evaluation of RDX

Abstract
Acute oral LD50's and standard errors were 119.0 + or - 4.6, 118.7 + or - 4.5, and 118.1 + or - 2.8 mg/kg in male, female and combined sexes of rates. The corresponding mouse LD50's were 97.2 + or - 8.7, 58.9 + or - 26.8, and 80.3 + or - 9.6 mg/kg, respectively. There were no statistically significant sex differences in either species. Toxic signs, including gasping, labored breathing and convulsions, indicated neurotoxicity. In the 90-day rat subchronic toxicity study, 40 mg/kg/day was toxic, while the next lower dose (28 mg/kg/day) was not. The only consistent toxic effect observed was decreased weight gain and (in males) decreased feed consumption in some week. RDX was not mutagenic in the Ames Salmonella/microsome test at doses up to 1 mg/plate and in the rat dominant lethal mutation test at doses up to 50 mg/kg/day. RDX was not teratogenic to rats or to rabbits at doses up to 20 mg/kg/day but at that dose produced severe nonteratogenic toxicity in rats. No adverse effects were observed at 2 mg/kg/ day. The two-generation reproduction study produced severe toxicity (particularly neurotoxic effects and unscheduled deaths) but no specifically reproductive toxicity at diets giving a nominal 50 mg/kg/day. Feeding 16 mg/kg/ day produced no apparent effects.

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