Isometric Detrusor Pressure during Bladder Filling and its Dependency on Bladder Volume and Interruption to Flow in Control Subjects

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Abstract
The isometric pressures generated by the bladder were studied during voluntary detrusor contraction and interruption of flow. Urodynamic studies were done in 34 healthy female volunteers, with a mean age of 29.6 +/- 9.3 yrs. Control urodynamics were done first to characterize bladder and urethral parameters to filling and voiding. Subsequently, isometric detrusor pressures were elicited during bladder filling at increments of 100 ml by asking subjects to attempt to void against a urethral obstruction produced by an inflated Foley balloon. Isometric pressures also were obtained by interruption of flow through the lumen of the 22F Foley catheter. The results showed that the maximum isometric pressure increase generated remained relatively constant during bladder filling at 39.6 +/- 13.1 cm water. This pressure is not significantly different from voiding pressures developed with a 10F urethral catheter. Isometric pressure increases during voiding showed that the increase in bladder pressure following interruption of flow was volume sensitive. The possibility that this volume dependency may result in errors in the interpretation of bladder contractility is discussed.

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