The Effects of Cardiac Pacing on Central Hemodynamics in Experimental Propoxyphene‐Induced Cardiac Failure

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Abstract
Coronary sinus pacing was evaluated in 10 pigs during propoxyphene‐induced cardiac failure. From baseline, propoxyphene chloride 15 mg. min‐1was infused until circulatory shock developed. Cardiac pacing was evaluated at different dose levels expressed as % of the shock dose of propoxyphene: at intoxication levels below 50% of the shock dose, cardiac pacing improved cardiac performance. At dose levels above 50% of the shock dose cardiac performance deteriorated further during pacing. The results are consistent with a severe negative inotropic effect of propoxyphene in overdose.