The Effect of Oral Doses of Sodium Fluoride on Blood Pressure in Dogs

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Abstract
Twelve mongrel dogs anesthetized with pentobarbital sodium given intravenously were observed for blood pressure responses to doses of NaF (10 mg F/ml) given by stomach tube. Intervals of 35 to 50 minutes intervened between sucessive doses of 1 mg F or 5 mg F. For larger doses (10-36 mg F/kg) only one dose was given. No significant fall in blood pressure was observed following a 1 mg F dose, after a 5 mg F dose (0.06-0.15 mg/kg), or after doses of 10 mg/kg. A hypotensive response was recorded in 2 of 3 dogs given 15 mg/kg. Doses of 23 mg F/kg or more invariably decreased blood pressure (3 dogs).

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