[Effect of some GABA, glycine, or glutamic acid derivatives on the forced swimming test in mice].

  • 1 January 1990
    • journal article
    • abstracts
    • Vol. 48  (3) , 154-9
Abstract
Three GABA derivatives, the GABA-steatamide (GS), the GABA-linoleamide (GL) and the progabide, two glycine derivatives, the glycine-steatamide (SG) and the glycine-linoleamide (LG) and, lastly, a glutamic acid derivative, the glutamic acid palmitamide (PGt), were studied in the forced swimming test (Porsolt's test) on mice. The anti-immobility effect, referring to the existence of antidepressive properties, was significant for the SG, LG, GL and PGt. It seems that the relative intensity of the anti-immobility effect on the one hand and the sedative properties on the other, could operate on the experimental profile of these derivatives in the Porsolt's test.

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