Two Lines of Walker Carcinoma 256: Their Peculiarities and Different Interactions with the Host

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Abstract
Two sublines of Walker 256 carcinoma have been characterized for their ability to metastasize and to induce cachexia. The invasive, metastasizing line A induced terminal anorexia in rats with a mean survival time of 27 ± 1.5 days. The non-invasive line B induced early anorexia and cachexia with a mean survival time of only 15 + 1 days. At death, the line B tumor was still smaller than the line A one, and no metastases were detectable. These two sublines are discussed as a composite model for studying anorexia and cachexia together with invasion and metastasis.