Cytogenetic abnormalities in a patient with hypercalcemia and papillary thyroid carcinoma
- 1 May 1982
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 60 (3) , 291-293
- https://doi.org/10.1007/bf00303024
Abstract
Cytogenetic examinations on multiple peripheral blood cultures of a patient with papillary thyroid carcinoma and hypercalcemia revealed the following features: (1) The average frequency of cells with aberrations was 11.6%, considerably higher than in controls. Among metaphases with chromosomal abnormalities, 4.5% had chromosome-type aberrations. (2) One homolog of chromosome 11 showed a fragile site in the proximal end of the long arm, and in three metaphases the segment distal to the fragile site showed “branched morphology.” (3) The rate of sister chromatid exchanges was within normal limits (8.78/metaphase). (4) The patient's two sons showed 7.0% and 5.0% abnormal metaphases, in the high normal range.This publication has 5 references indexed in Scilit:
- The incidence of unstable chromosome aberrations in peripheral blood lymphocytes from unirradiated and occupationally exposed peopleMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
- HERITABLE FRAGILE SITES ON HUMAN-CHROMOSOMES .2. DISTRIBUTION, PHENOTYPIC EFFECTS, AND CYTOGENETICS1979
- Inherited constriction fragility of chromosome 2.1973