The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1
- 1 May 2000
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 25 (1) , 19-21
- https://doi.org/10.1038/75546
Abstract
The gene encoding the insulin-like growth-factor type-2 receptor (Igf2r) is maternally expressed and imprinted1. A CpG island in Igf2r intron 2 that carries a maternal-specific methylation imprint2 was shown in a transgenic model to be essential for Igf2r imprinting and for the production of an antisense RNA from the paternal allele3. We report here that the endogenous region2 is the promoter for this antisense RNA (named Air, for antisense Igf2r RNA) and that the 3′ end lies 107,796 bp distant in an intron of the flanking, but non-imprinted4,5, gene Mas1.Keywords
This publication has 14 references indexed in Scilit:
- An imprinted antisense RNA overlaps UBE3A and a second maternally expressed transcriptNature Genetics, 1998
- Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoterNucleic Acids Research, 1998
- Competition- a common motif for the imprinting mechanism?The EMBO Journal, 1997
- Imprinted expression of the Igf2r gene depends on an intronic CpG islandNature, 1997
- Characterization of the C3 YAC Contig from Proximal Mouse Chromosome 17 and Analysis of Allelic Expression of Genes Flanking the Imprinted Igf2r GeneGenomics, 1997
- The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their ExpressionGenomics, 1996
- Expression of the mouse and rat mas proto‐oncogene in the brain and peripheral tissuesFEBS Letters, 1995
- Parental imprinting of the Mas protooncogene in mouseNature Genetics, 1994
- Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signalCell, 1993
- The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locusNature, 1991