Stereochemistry of porphyrinogen carboxy-lyase reaction in haem biosynthesis
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 494-496
- https://doi.org/10.1039/c39750000494
Abstract
Stereospecifically deuteriated and tritiated succinate was incorporated into the acetate residues of uroporphyrinogen III which on decarboxylation generated asymmetric methyl groups in coproporphyrinogen III and then in haem; degradation of the latter yielded chiral acetate deriving from the C and D rings of haem and configurational analysis of this derived acetate shows that the carboxy-lyase reaction proceeds with a retention of configuration.Keywords
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