Surgical treatment and adjuvant chemotherapy of gastric cancer on the basis of pathological findings.

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Abstract
Gastrectomy was performed in 626 of 692 operated cases of gastric cancer. Histologic examination of the resected specimens revealed that the cancer was confined to the mucosal (m) or submucosal layer (sm) in 256 patients, advanced to the muscularis propria (pm) or subserosal layer (ss) in 110 and to the serosa (se) or surrounding organs (si, sei) in 260, 238 (93%) of m and sm cases were free from lymph node metastasis. Lymph node metastases was noted in 51 (46%) of pm and ss cases. In 229 se cases, 177 (77%) were positive for lymph node metastases and 108 (47%) showed metastases in n2 and n3 degrees. Adjuvant chemotherapy improved the postoperative survival rate of advanced cases with lymph node metastases, serosal involvement or lymph and blood vessel involvement of gastric cancer.

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