Incorporation of Selenium into Spermatogenic Pathway in Mice.

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Abstract
Following subcutaneous administration of tracer Se-75 (1 [mu]c Se-75; 0.03 [mu]g Se) to mature male CD-1 mice, highest concentrations were found in kidney, liver, GI tract and injected leg by 1 hr., in blood, lungs, pancreas, heart and skeletal muscle by 4 hr., and in spleen and non-injected leg by 1 day. In contrast, testis, one of the lowest ranking in Se-75 at 1 hr., continued to cumulate this element. By 7 days testis was 3.5 times greater in Se-75 concentration than at 1 hr. and was now the 3rd ranking tissue, after liver and kidney. As Se-75 fell in testis, it rose in epididymis, reaching maximal levels by 2 to 3 weeks. When Se-75 (1 [mu]c) was administered with carrier (72 [mu]g Se), testis had peak levels by 30 min. Although at 1st there was a flushing out of initial high levels of Se-75 in testis (as has been noted for most tissues) there was, as with the tracer dose, a cumulation pattern from the 2nd day to the 1st week time-period and a subsequent fall by the 2nd week. Association of Se-75 with the wave of spermatogenesis in the face of its depletion in other tissues, and its seeming lack of toxicity to male fertility in doses which interfere drastically with reproduction in females, suggests that this element is capable of entering some established metabolic pathway in the male reproductive system with no apparent adverse effects.

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