Abstract
Three articles in this issue of the Journal describing noxious effects of therapeutic or diagnostic chemicals once again point up this vexing problem. Although most of the sick benefit from their contact with the treasure chest of modern pharmacotherapy, the experience is unhappy for too many. Several recent studies have quantitated drug-related morbidity, sequelae and mortality in hospitalized patients.1 2 3 About 5 per cent of all inpatients suffer adverse drug reactions severe enough to cause marked morbidity, prolong hospitalization, result in permanent sequelae or contribute to a fatal outcome. The risks for outpatients are also considerable, and 3 to 4 per . . .

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