Activated Fc Alpha T Cells in Crohn’s Disease are Involved in Regulation of IgA

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Abstract
In patients with Crohn’s disease (CD) elevated number of peripheral T cells exhibit activation associated determinants on their cells surface (l–3). The number of activated peripheral T cells (APT) is correlated to the clinical activity (2), to the number of activated T cells in the inflamed mucosa and to the pathohistological features of ileal biopsies (4). One possible explanation of the close relationship between inflammation in the mucosa and peripheral activation of lymphocytes could be an origin of APT from inflamed areas of the gut mucosa. Since IgA is the major isotype of the humoral immune response of the gut associated lymphoid tissue (Galt), APT were analysed in regard to their ability to modulate IgA secretion of autologous B cells.