Oxidized Low Density Lipoprotein : The Occurrence and Metabolism in Circulation and in Foam Cells
Open Access
- 1 January 2000
- journal article
- review article
- Published by Japan Atherosclerosis Society in Journal of Atherosclerosis and Thrombosis
- Vol. 7 (3) , 123-131
- https://doi.org/10.5551/jat1994.7.123
Abstract
Oxidatively-modified low-density lipoprotein (OxLDL) is thought to be involved in the early development of atherosclerotic lesions. The appearance of lipid-laden foam cells is known to be one of the typical features of atherosclerotic lesions, and accumulating evidence has demonstrated that foam cells are formed after taking up OxLDL by macrophages in vitro. However, the modified structures, distribution, and metabolism of OxLDL present in vivo are poorly understood. Recently, our studies, together with others, have demonstrated that OxLDL is actually present in circulating human plasma. Furthermore, we have provided evidence that foam cells accumulate modified apoB fragments derived from OxLDL in the cells. This article reviews recent progress in this field, including the intracellular metabolism of OxLDL in foam cells and the relevance of OxLDL as an in vivo ligand for macrophages.Keywords
This publication has 38 references indexed in Scilit:
- Deposition of oxidized low-density lipoprotein and collagenosis occur coincidentally in human coronary stenosisCoronary Artery Disease, 1998
- Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene.Journal of Clinical Investigation, 1997
- An endothelial receptor for oxidized low-density lipoproteinNature, 1997
- The Advanced Glycation End Product, N∊-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation ReactionsJournal of Biological Chemistry, 1996
- Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.Journal of Clinical Investigation, 1995
- Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease.Journal of Clinical Investigation, 1995
- Generation, Characterization, and Histochemical Application of Monoclonal Antibodies Selectively Recognizing Oxidatively Modified ApoB-Containing Serum LipoproteinsArteriosclerosis, Thrombosis, and Vascular Biology, 1995
- Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages.Journal of Clinical Investigation, 1994
- Apolipoprotein B of oxidized LDL accumulates in the lysosomes of macrophagesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1994
- Stimulation with a monoclonal antibody (mAb4E4) of scavenger receptor-mediated uptake of chemically modified low density lipoproteins by THP-1-derived macrophages enhances foam cell generation.Journal of Clinical Investigation, 1994