2 CASES OF SUPERFICIAL PEMPHIGUS INDUCED BY PYRITINOL

  • 1 January 1978
    • journal article
    • research article
    • Vol. 105  (6-7) , 573-577
Abstract
Pyritinol is presently prescribed in rheumatoid polyarthritis because of its structural analogy to D-penicillamine. Previously, only benign cutaneous side effects were mentioned. Two cases of pemphigus are reported which occurred during pyritinol therapy given for rheumatoid polyarthritis and memory deficiency. Clinical findings was that of a superficial pemphigus. The histological picture was of a superficial acantholysis or an eosinophilic spongiosis. Definite proof of pemphigus was shown by the presence of anti-intercellular substance antibodies in the serum and skin of both patients.

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