Amino Acids and Peptides; 70.1Optically Active α-Amino Acids,N-Boc-Aminoaldehydes and α-Amino-β-hydroxy Acid from 2,3-Epoxy Alcohols
- 1 January 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1989 (04) , 256-261
- https://doi.org/10.1055/s-1989-27216
Abstract
Trichloroacetimidic esters of 2,3-epoxy alcohols are transformed into oxazolines 5 and dihydrooxazines 6, respectively, depending on the structure of the educts and the catalyst. The five-membered ring compounds 5 are transformed into erythro-α-amino-β-hydroxy acids (60-70% from epoxy alcohols) via oxazolidinones 11, 12, and 13. α-Amino acids and α-substituted α-amino acids 10 as well as the corresponding aldehydes 9 are obtained from the dihydrooxazines 6 (50-60% from epoxy alcohols).Keywords
This publication has 0 references indexed in Scilit: