Lipase-catalysed asymmetric and enantioselective esterification of spiro[3.3]heptanes in organic solvents
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- Vol. 23 (11) , 2891-2892
- https://doi.org/10.1039/p19910002891
Abstract
Lipase-catalysed asymmetric esterification of 2,2,6,6-tetrakis(hydroxymethyl)spiro[3.3]heptane in both isopropyl ether and pyridine gave regiospecifically 2,6-bis(acetoxymethyl)-2,6-bis(hydroxymethyl)spiro[3.3]heptane having axial chirality and moderate optical purity. Similarly, racemic diols of spiro compounds having axial chirality were resolved by lipase-catalysed enantioselective esterification in isopropyl ether.Keywords
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