Clinical evaluation of a new anthelmintic — C.9333 Go./CGP 4540 in human hookworm infection
- 1 January 1977
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 71 (3) , 247-250
- https://doi.org/10.1016/0035-9203(77)90017-7
Abstract
A new antihookworm compound, C.9333 Go./CGP 4540, was evaluated clinically in 65 adult patients with hookworm infection. Several dosage schedules were evaluated to determine an effective, well tolerated and convenient regime. The lowest effective dose was 125 mg administered at four-hourly intervals for three doses. The compound was generally well tolerated; mild giddiness was observed in nine patients and severe giddiness was present in one patient. Clinical and biochemical monitoring revealed no other toxicity of the compound.Keywords
This publication has 2 references indexed in Scilit:
- 4-Isothiocyanato-4′-nitrodiphenylamine (C9333-Go/CGP 4540) an anthelminthic with an unusual spectrum of activity against intestinal nematodes, filariae and schistosomesCellular and Molecular Life Sciences, 1976
- Clinical trials with a new anthelminthic, tetramisoleTransactions of the Royal Society of Tropical Medicine and Hygiene, 1970