Opsonin-Independent Phagocytosis by Human Alveolar Macrophages: Augmentation by Human Plasma Fibronectin1-2
- 1 May 1982
- journal article
- research article
- Published by American Thoracic Society in American Review of Respiratory Disease
- Vol. 125 (5) , 607-609
- https://doi.org/10.1164/arrd.1982.125.5.607
Abstract
A trypsin-sensitive membrane recognition unit that mediates phagocytosis of particulate activators of the human alternative complement pathway is present on human alveolar macrophages. Fragmented human plasma fibronectin selected by affinity chromatography with a monoclonal antif ibronectin antibody augments this capacity. These data suggest a nonimmune mechanism for the clearance of some microorganisms from the opsonin-deficient microenvironment of the lung in which the alveolar macrophage is the principal resident phagocyte.This publication has 10 references indexed in Scilit:
- Human alveolar macrophage fibronectin: synthesis, secretion, and ultrastructural localization during gelatin-coated latex particle bindingThe Journal of cell biology, 1981
- Augmentation of human monocyte opsonin-independent phagocytosis by fragments of human plasma fibronectin.Proceedings of the National Academy of Sciences, 1981
- Interaction between human neutrophils and zymosan particles: the role of opsonins and divalent cations.The Journal of Immunology, 1981
- Functional discrimination by human monocytes between their C3b receptors and their recognition units for particulate activators of the alternative complement pathway.The Journal of Immunology, 1980
- Fibronectin is produced by human macrophages.The Journal of Experimental Medicine, 1980
- Membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes.Proceedings of the National Academy of Sciences, 1978
- Affinity of fibronectin to collagens of different genetic types and to fibrinogen.The Journal of Experimental Medicine, 1978
- Opsonin-Independent Phagocytosis of Activators of the Alternative Complement Pathway by Human MonocytesThe Journal of Immunology, 1978
- 2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages. I. Description of the inhibitory effect.The Journal of Experimental Medicine, 1976
- Bronchopulmonary Lavage in Normal Subjects and Patients with Obstructive Lung DiseaseAnnals of Internal Medicine, 1967