Opposite Modulation of Cocaine-Seeking Behavior by D 1 - and D 2 -Like Dopamine Receptor Agonists
- 15 March 1996
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 271 (5255) , 1586-1589
- https://doi.org/10.1126/science.271.5255.1586
Abstract
Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior. We found that this “priming” effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior. These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.Keywords
This publication has 26 references indexed in Scilit:
- Biochemical adaptations in the mesolimbic dopamine system in response to heroin self‐administrationSynapse, 1995
- The dopamine D3 receptor: Chinese hamsters or Chinese Whispers?Trends in Pharmacological Sciences, 1994
- Individual Differences in Locomotor Activity Are Associated with Levels of Tyrosine Hydroxylase and Neurofilament Proteins in the Ventral Tegmental Area of Sprague-Dawley RatsMolecular and Cellular Neuroscience, 1993
- The D1 agonists SKF 82958 and SKF 77434 are self-administered by ratsBrain Research, 1992
- Molecular biology of dopamine receptorsTrends in Pharmacological Sciences, 1992
- D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal NeuronsScience, 1990
- Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacyEuropean Journal of Pharmacology: Molecular Pharmacology, 1990
- Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbensPharmacology Biochemistry and Behavior, 1980
- Multiple receptors for dopamineNature, 1979
- On the role of ascending catecholaminergic systems in intravenous self-administration of cocainePharmacology Biochemistry and Behavior, 1977