Subunit A of Factor XIII Regulates Subunit B Plasma Concentration

1 January 1981

journal article
research article
Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis

Vol. 46 (03) , 621-622
https://doi.org/10.1055/s-0038-1653431

Abstract

Subunit a of Factor XIII is found absent in homozygotes and reduced in heterozygotes. Since a concomitant reduction of subunit b occurs in these cases, an interaction between the loci controlling the synthesis of the two subunits was suggested. However in the present study we have shown that the administration of subunit a in two totally devoid homozygotes produced an increase of subunit b, reaching the maximum concentration five days after infusion. This strongly suggests that subunit b plasma level is regulated on the subunit a plasma amount.

Keywords

This publication has 1 reference indexed in Scilit:

Subunits A and S Inheritance in Four Families with Congenital Factor XIII Deficiency
British Journal of Haematology, 1978