Self-Sorting of White Blood Cells in a Lattice
- 15 September 1997
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 79 (11) , 2149-2152
- https://doi.org/10.1103/physrevlett.79.2149
Abstract
When a drop of human blood containing red and white blood cells is forced to move via hydrodynamic forces in a lattice of channels designed to mimic the capillary channels, the white cells self-fractionate into the different types of white cells. The pattern of white cells that forms is due to a combination of stretch-activated adhesion of cells with the walls, stochastic sticking probabilities, and heteroavoidance between granulocytes and lymphocytes.Keywords
This publication has 11 references indexed in Scilit:
- Biotechnology at low Reynolds numbersBiophysical Journal, 1996
- Neutrophil rolling altered by inhibition of L-selectin shedding in vitroNature, 1996
- Adhesion through L-selectin requires a threshold hydrodynamic shearNature, 1996
- Compression-induced changes in the shape and volume of the chondrocyte nucleusJournal of Biomechanics, 1995
- Fabrication of Submicrometer Features on Curved Substrates by Microcontact PrintingScience, 1995
- Deformation and flow of red blood cells in a synthetic lattice: evidence for an active cytoskeletonBiophysical Journal, 1995
- Statistical Mechanics of Membrane Adhesion by Reversible Molecular BondsPhysical Review Letters, 1995
- DNA electrophoresis in microlithographic arraysNature, 1992
- Multivariate chromosome analysis and complete karyotyping using dual labeling and fluorescence digital imaging microscopyCytometry, 1990
- Apparent viscosity and cortical tension of blood granulocytes determined by micropipet aspirationBiophysical Journal, 1989