INFLUENCE OF SELECTIVE THROMBOCYTOPENIA ON NEPHROTOXIC NEPHRITIS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 87  (6) , 967-975
Abstract
Anticoagulation with agents that interfere with fibrin formation inhibit the development of the autologous phase of nephrotoxic nephritis (NTN). Platelet participation in the nephritic process has been suggested but nor proved, therefore, the influence of selective thrombocytopenia on the autologous phase in rabbits was evaluated. NTN was produced with goat antirabbit glomerular basement membrane antiserum. Thrombocytopenia was induced with goat antirabbit platelet antiserum 24 h prior to the onset of nephritis. Platelet accumulation within the nephritic kidney was quantitated using Cr labeled platelets. Thrombocytopenia has no inhibitory effect on the development of the autologous phase of NTN in rabbits. There was no platelet accumulation within the nephritic kidney in the presence of thrombocytopenia. Pharmacologic inhibition of a platelet aggregation may be of no benefit in glomerulonephritis produced by a fixed antigen-antibody reaction within the glomerular capillary wall.

This publication has 4 references indexed in Scilit: