Cytomegalovirus Ventriculoencephalitis in a Bone Marrow Transplant Recipient Receiving Antiviral Maintenance: Clinical and Molecular Evidence of Drug Resistance
Open Access
- 1 November 2001
- journal article
- case report
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 33 (9) , e105-e108
- https://doi.org/10.1086/323022
Abstract
We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.Keywords
This publication has 17 references indexed in Scilit:
- Sequencing of Cytomegalovirus UL97 Gene for Genotypic Antiviral Resistance TestingAntimicrobial Agents and Chemotherapy, 2001
- Resistance of Human Cytomegalovirus to Antiviral DrugsClinical Microbiology Reviews, 1999
- High‐Level Resistance of Cytomegalovirus to Ganciclovir Is Associated with Alterations in Both the UL97 and DNA Polymerase GenesThe Journal of Infectious Diseases, 1997
- Antiviral Susceptibilities and Analysis of UL97 and DNA Polymerase Sequences of Clinical Cytomegalovirus Isolates from Immunocompromised PatientsThe Journal of Infectious Diseases, 1997
- Cytomegalovirus EncephalitisAnnals of Internal Medicine, 1996
- Clinical Impact of Cytomegalovirus Infections of the Nervous System in Patients with AIDSClinical Infectious Diseases, 1995
- The development of cytomegalovirus encephalitis in AIDS patients receiving ganciclovirThe American Journal of Medicine, 1994
- Cytomegalovirus encephalitis in acquired immunodeficiency syndrome (AIDS)Neurology, 1994
- Cytomegalovirus Ventriculoencephalitis in AIDSMedicine, 1993
- Cytomegalovirus Infections After Allogeneic Bone Marrow TransplantationClinical Infectious Diseases, 1990