Autoinducer of Virulence As a Target for Vaccine and Therapy AgainstStaphylococcus aureus
- 17 April 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 280 (5362) , 438-440
- https://doi.org/10.1126/science.280.5362.438
Abstract
Staphylococcus aureuscauses pathologies ranging from minor skin infections to life-threatening diseases. Pathogenic effects are largely due to production of bacterial toxin, which is regulated by an RNA molecule, RNAIII. TheS. aureusprotein called RAP (RNAIII activating protein) activates RNAIII, and a peptide called RIP (RNAIII inhibiting peptide), produced by a nonpathogenic bacteria, inhibits RNAIII. Mice vaccinated with RAP or treated with purified or synthetic RIP were protected fromS. aureuspathology. Thus, these two molecules may provide useful approaches for the prevention and treatment of diseases caused byS. aureus.Keywords
This publication has 21 references indexed in Scilit:
- The prospects for developing a vaccine against Stapphylococcus aureusTrends in Microbiology, 1996
- Polysaccharide Conjugate Vaccines for the Prevention of Gram-Positive Bacterial InfectionsPublished by Springer Nature ,1996
- Cell density control of staphylococcal virulence mediated by an octapeptide pheromone.Proceedings of the National Academy of Sciences, 1995
- Translation of RNAIII, theStaphylococcus aureusagr regulatory RNA molecule, can be activated by a 3′-end deletionFEMS Microbiology Letters, 1995
- A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa.Proceedings of the National Academy of Sciences, 1995
- IntroductionPublished by Springer Nature ,1995
- Gram-negative bacterial communication by N-acyl homoserine lactones: a universal language?Trends in Microbiology, 1994
- Biochemical and genetic characterization of a competence pheromone from B. subtilisCell, 1994
- Genetics and mechanisms of glycopeptide resistance in enterococciAntimicrobial Agents and Chemotherapy, 1993
- Co-transfer of vancomycin and other resistance genes fromEnterococcus faecalisNCTC 12201 toStaphylococcus aureusFEMS Microbiology Letters, 1992