Relative efficacy of chelating agents as antidotes for acute gallium nitrate intoxication

1 February 1987

journal article
letter
Published by Springer Nature in Archives of Toxicology

Vol. 59 (5) , 382-383
https://doi.org/10.1007/bf00295095

Abstract

Twelve chelating agents were administered to mice by IP injection to compare their relative effectiveness in preventing death after a single IP injection of gallium nitrate. Na₂Ca-ethylenediaminetetraacetate (EDTA), Na₃Ca-diethylenetriaminepentaacetate (DTPA), dimercaptosuccinic acid (DMSA), 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron), sodium diethyldithiocarbamate (DDC), L-cysteine and sodium salicylate were not effective for acute gallium nitrate intoxication. The therapeutic indices of the effective chelators were: 25.4 (deferoxamine mesylate), 35.7 (citric acid), 42.3 (succinic acid), 52.2 (malic acid) and 111.1 (oxalic acid).

Keywords

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