The demethylation of griseofulvin by fungi
Open Access
- 1 July 1961
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 80 (1) , 34-37
- https://doi.org/10.1042/bj0800034
Abstract
Incubation of griseofulvin with fungi gave rise to various demethylated metabolites. Thus, 7-chloro-4-hydroxy-62[image]-dimethoxy-6[image]-methylgris-2[image]-en-3:4[image]-dione (4-demethylgriseofulvin) was produced by Microsporum canis, griseofulvic acid (2[image]-demethylgriseofulvin) by Botrytis allii and 7-chloro-6-hydroxy-4:2[image]-dimethoxy-6[image] - methylgris-2[image]-en-3:4[image]-dione (6-demethyl-griseofulvin) by Cercospora melonis.This publication has 4 references indexed in Scilit:
- The metabolism of griseofulvin in mammalsBiochemical Journal, 1961
- Mycological Aspects of Action of Griseofulvin Against DermatophytesArchives of Dermatology, 1960
- Uptake and translocation of organic compounds by fungiExperimental Cell Research, 1959
- Studies on the Biological Activity of GriseofulvinAnnals of Botany, 1949