Genetic and biochemical analyses of yeast RNase MRP
- 1 January 1996
- journal article
- review article
- Published by Springer Nature in Molecular Biology Reports
- Vol. 22 (2-3) , 75-79
- https://doi.org/10.1007/bf00988709
Abstract
RNase MRP cleaves the yeast pre-rRNA at a site in internal transcribed spacer 1 (ITS1) and this cleavage can be reproducedin vitro by the highly purified enzyme. Two protein components (Pop1p and Pop2p) have been identified which are common to yeast RNase MRP and RNase P. Moreover, purified RNase P can also cleave the pre-rRNA substratein vitro, underlining the similarities between these particles. Genetic evidence suggests that RNase MRP functionally interacts with the snoRNPs which are required for other pre-rRNA processing reactions.Keywords
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