Interaction Between Acetohydroxamic Acid and 12 Antibiotics Against 14 Gram-Negative Pathogenic Bacteria
- 1 February 1974
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 5 (2) , 106-110
- https://doi.org/10.1128/aac.5.2.106
Abstract
Acetohydroxamic acid (AHA) is a potent inhibitor of urease which prevents alkalinization of urine and stone formation in rats in the presence of infection caused by urease-producing bacteria. Because an antibacterial effect of AHA, and synergy between kanamycin and AHA have also been described, we studied the interaction between AHA and 12 antibiotics against 14 gram-negative bacteria. Synergy, sometimes to a striking degree, was found in 17% of interactions; however, antagonism was detected in 5%. Infecting organisms would need to be studied individually before the antibacterial effect of AHA and an antibiotic could be predicted.Keywords
This publication has 8 references indexed in Scilit:
- Inhibition of bacterial urease.1973
- Prevention of infected urinary stones by urease inhibition.1973
- Synthesis and Metabolism of Labeled Acetohydroxamic Acid, a Urease InhibitorExperimental Biology and Medicine, 1971
- Urease Inhibitors for Hepatic Coma. II. Comparative Efficacy of Four Lower Hydroxamate Homologs in Vitro and in VivoExperimental Biology and Medicine, 1970
- Physiologic disposition of short chain aliphatic hydroxamates in the mouse. I. The one-through-four carbon hydroxamates: excretion and conversion to amides.1970
- Ammonia Production in the Human ColonNew England Journal of Medicine, 1970
- Preparation and some properties of stable and carbon-14 and tritium-labeled short-chain aliphatic hydroxamic acidsAnalytical Biochemistry, 1969
- Effects of Urease Inhibition in Hyperammonemia: Clinical and Experimental Studies with Acetohydroxamic AcidGastroenterology, 1968