Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by phenolic constituents of mulberry tree.

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Abstract
CAMP phosphodiesterase inhibition by phenolic constituents of mulberry tree was studied. The structure-inhibitory activity relationships were studied in 56 derivatives of prenylflavonoids, prenylchalcones and Diels-Alder type adducts. Diels-Alder type adducts of chalcones and dehydroprenylflavonoids or dehydroprenyl-2-arylbenzofurans differed from prenylflavonoids and prenylchalcones in the inhibitory activity and inhibitory type (determined by means of Dixon plots).

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