The non‐peptide NK1 receptor antagonist, (±)‐CP‐96,345, produces antinociceptive and anti‐oedema effects in the rat
Open Access
- 1 March 1992
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 105 (3) , 508-510
- https://doi.org/10.1111/j.1476-5381.1992.tb09008.x
Abstract
The non‐peptide NK1 receptor antagonist, (±)‐CP‐96,345, has been evaluated for antinociceptive activity in two well‐characterized inflammatory pain models in the rat. (±)‐CP‐96,345 abolished carrageenin‐induced mechanical hyperalgesia, significantly reduced carrageenin‐induced paw oedema and attenuated the second phase of the formalin response. The results suggest that NK1 receptor activation occurs during the induction of inflammatory pain states in the rat.Keywords
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