Absorption of human α2-macroglobulin with selected strains of streptococci
- 1 May 1983
- journal article
- Published by Springer Nature in Medical Microbiology and Immunology
- Vol. 172 (1) , 33-39
- https://doi.org/10.1007/bf02123675
Abstract
A new interaction was observed between humanα 2-macroglobulin (α 2M) and selected strains of streptococci. The streptococci boundα 2M. After its elution from the bacteria,α 2M was demonstrated by immunoelectrophoresis against anti-humanα 2M. The binding ofα 2M to one streptococcal strain of serological group C and two of group G was confirmed by radial immunodiffusion. Treating the streptococci with trypsin reduced their reactivity withα 2M. On the other hand, prolonged treatment with 6M guanidine-HCl had no effect on theα 2M binding. Binding sites forα 2M were most likely protein structures on the streptococcal surface.Keywords
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