COMPARISON OF SULFOBROMOPHTHALEIN AND INDOCYANINE GREEN CLEARANCES IN THE CAT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (4) , 727-729
Abstract
Plasma disappearances of sulfobromophthalein (BSP) and indocyanine green (ICG) given in single-dose iv injections to cats were measured. The BSP was given at a dose of 5 mg/kg of body wt; ICG was given at a dose of 1.5 mg/kg of body wt. The half-life, disappearance rate (%/min) and clearance (ml/min per kg) were determined during the initial phase of plasma dye elimination. The half-life for BSP was 2.2 .+-. 0.7 min, and for ICG, 3.8 .+-. 0.9 min. The disappearance rate for BSP was 34.7 .+-. 10.1, and for ICG, 19.2 .+-. 4.5. The clearance for BSP was 26.3 .+-. 23.1 and for ICG, 8.6 .+-. 4.1. The 30-min percentage retention for BSP was 0.6 .+-. 0.8% and for ICG, 7.3 .+-. 2.9%. In the cat, ICG was cleared from the plasma less rapidly than BSP. There were no significant differences between males and females for these values. For both BSP and ICG, a significantly shorter half-life, faster disappearance rate and lower 30-min percentage retention were observed in the cat, compared with values observed in the dog given similar dye dosages. Clearance curves for BSP and ICG in the cat were similar to those in the dog, indicating that the 2 species may have similar volumes of dye distribution and excretory mechanisms. The 30-min plasma level following a 5 mg/kg dose of BSP in normal cats is often too low for measurement, whereas the 30-min plasma concentration of ICG following a 1.5 mg/kg dose is adequate. For the 30-min dye retention test in the cat, ICG may be a preferred diagnostic agent.