Synthesis of Two Tumor-Associated Oligosaccharides: Di- and Trifucosylated Para-Lacto-N-Hexaose
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 10 (6) , 1023-1048
- https://doi.org/10.1080/07328309108543970
Abstract
Di- and trifucosylated derivatives (21 and 22) of para-lacto-N-hexaose were synthesized. Both structures have been shown to be present in small quantities in human milk, and have also been indicated as tumor-associated antigens. Thioglycoside mono- and disaccharide blocks were used to assemble a properly protected linear hexaose. Di- and trifucosylation at appropriate positions followed by deprotection then gave the desired oligosaccharides.Keywords
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