Lipase-catalysed enantioselective ring-opening of oxazol-5(4H)-ones coupled with partial in situ racemisation of the less reactive isomer
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1091-1092
- https://doi.org/10.1039/c39900001091
Abstract
2-Phenyl-4-methyl-oxazol-5(4H)-one undergoes lipase-catalysed enantioselective ring-opening with butan-1-ol in di-isopropyl ether; the less reactive isomer of the oxazolone further undergoes partial in situ racemisation under the reaction conditions to afford, after quantitative conversion, butyl N-benzoylalaninate enriched in one isomer.Keywords
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