The Dose-Response Effects of Nifedipine of ST-Segment Changes in Exercise Testing: Preliminary Studies

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Abstract
The effects of increasing doses of nifedipine on exercise-induced ST-segment depression were examined in patients with severe typical angina pectoris. Ten patients underwent four 1-wk treatment periods in a single-blind clinical trial. These were nifedipine 0, 30, 60 and 90 mg in divided doses daily. At the end of each week a maximum exercise test was performed using 16 precordial ECG leads and the ST-segment changes measured immediately after exercise. In 4 patients, nifedipine produced no effects on these ECG parameters; 4 patients improved and 2 deteriorated. A dose of nifedipine, effective in one patient, can have opposite effects in another.

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