Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine
- 13 December 1968
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3859) , 1290-1292
- https://doi.org/10.1126/science.162.3859.1290
Abstract
Tolerance and physical dependence development to morphine in mice can be prevented by concomitant administration of cycloheximide. The fact that the rate of synthesis of brain 5-hydroxytryptamine (5HT) increases with tolerance to morphine suggests that the protein involved may be associated with 5HT synthesis. Inhibition of this synthesis with p-chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine.Keywords
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