EVIDENCES FOR DUODENO-PANCREATIC REFLEXES AND AN ANTI-CCK FACTOR WITH LIDOCAINE INFUSED INTRAVENOUSLY AND SPRAYED TOPICALLY ON PANCREATIC PAPILLA IN NONALCOHOLIC AND ALCOHOL-FED DOGS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 66  (3) , 221-240
Abstract
In 14 duodenal Thomas fistula dogs [4 alcohol-fed for 2 years] lidocaine, applied topically to the duodenal pancreatic papilla, inhibited secretin-induced pancreatic secretion probably by interrupting duodenopancreatic reflexes that contribute to pancreatic cholinergic tone. Opposite effects were observed with lidocaine administered against a CCK [cholecystokinin] plus secretin background stimulation. The significant increase in volume and protein output above plateau levels was enhanced by chronic alcohol feeding. I.v. lidocaine infusion did not alter secretin-induced pancreatic secretion but increased CCK and secretin evoked plateau secretion levels. Chronic alcohol feeding enhanced these latter effects. Atropine perfusion superimposed on CCK and secretin stimulation did not prevent but increased the i.v. lidocaine-induced pancreatic secretion changes. The modifications elicited by lidocaine sprayed topically and infused i.v. on CCK plus secretin-evoked pancreatic secretion plateau levels possibly are due to depression of an anti-CCK factor secreted by the small intestine mucosa.

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