More on Vincristine in Treatment of ITP

Abstract
To the Editor: The recent reopening of the Correspondence columns in the Journal to the treatment of chronic idiopathic thrombocytopenic purpura (ITP) with vincristine (N Engl J Med 297:397, 1977) encourages us to report on our experience with 26 patients (18 adults and eight children). All had previously received steroids, and only 14 had shown a temporary improvement. Three had not benefited from splenectomy either. Vincristine was given by weekly intravenous injections (2 mg for adults and 1 mg for children) until either a maximal platelet response occurred or unacceptable neurotoxicity appeared. The total number of injections ranged between . . .

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