The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?
Open Access
- 1 March 2004
- journal article
- review article
- Published by Elsevier in Molecular Pharmacology
- Vol. 65 (3) , 479-487
- https://doi.org/10.1124/mol.65.3.479
Abstract
Renal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a detailed understanding of this pathway for the development of optimum therapeutics. With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion secretion has entered the molecular age. In this review, we focus on various aspects of the molecular biology and pharmacology of the OATs, including discussion of their structural biology, genomic organization in pairs, developmental regulation, toxicology, and pharmacogenetics. We propose functional, pathophysiological, and evolutionary hypotheses to help explain recent experimental and genomic data.Keywords
This publication has 92 references indexed in Scilit:
- Structure and Mechanism of the Lactose Permease of Escherichia coliScience, 2003
- Interaction of Cysteine Conjugates with Human and Rabbit Organic Anion Transporter 1The Journal of Pharmacology and Experimental Therapeutics, 2003
- Systematic functional analysis of the Caenorhabditis elegans genome using RNAiNature, 2003
- Differential Gene Expression of Organic Anion Transporters in Male and Female RatsBiochemical and Biophysical Research Communications, 2002
- Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteinsJournal of Human Genetics, 2001
- Isolation of a Family of Organic Anion Transporters from Human Liver and KidneyBiochemical and Biophysical Research Communications, 2001
- Discovery and modeling of transcriptional regulatory regionsPublished by Elsevier ,2000
- A Novel Putative Transporter Maps to the Osteosclerosis (oc) Mutation and Is Not Expressed in theocMutant MouseGenomics, 1999
- Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the KidneyPublished by Elsevier ,1997
- Enhancement of p-aminohippurate accumulation in renal cortical slices after repeated administrations of various organic anionic drugs to rats of different agesCellular and Molecular Life Sciences, 1978