Genetic manipulation of the renin–angiotensin system in the kidney
- 1 September 2001
- journal article
- review article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 173 (1) , 67-73
- https://doi.org/10.1046/j.1365-201x.2001.00886.x
Abstract
Over the past 5 years, genetic manipulation has revolutionized the way we examine physiological processes by providing a targeted specificity that was not possible previously. The application of transgenesis and gene targeting has been applied to numerous physiological pathways; and both will remain important tools as we reach the completion of the human genome project and begin to assess the function of newly identified genes. The renin–angiotensin system (RAS) has been the target of numerous transgenic and gene targeting studies designed to help uncover its role in cardiovascular regulation and organ development. Each gene of the system has now been both over-expressed and knocked out. It will be discussed as to how new advances in tissue-specific gene targeting by both over-expression and gene ablation can be used as powerful tools to dissect the role of the RAS in individual tissues.Keywords
This publication has 36 references indexed in Scilit:
- Divergent functions of angiotensin II receptor isoforms in the brainJournal of Clinical Investigation, 2000
- Impaired Endothelial Function in Transgenic Mice Expressing Both Human Renin and Human AngiotensinogenStroke, 2000
- Efficient Liver-specific Deletion of a Floxed Human Angiotensinogen Transgene by Adenoviral Delivery of Cre Recombinasein VivoPublished by Elsevier ,1999
- Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre RecombinaseJournal of Biological Chemistry, 1999
- Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes.Journal of Clinical Investigation, 1996
- Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na–Cl cotransporterNature Genetics, 1996
- Renin expression in renal proximal tubule.Journal of Clinical Investigation, 1993
- Angiotensin II: a powerful controller of sodium transport in the early proximal tubule.Hypertension, 1990
- In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system.Journal of Clinical Investigation, 1990
- Angiotensin-Converting Enzyme in the Rat KidneyNephron, 1990